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The mouse viral outgrowth assay: avatars for the detection of HIV-1 reservoirs
Kelly A Metcalf Pate1, Joel N Blankson2,3
1Department of Molecular and Comparative Pathobiology, Center for AIDS Research, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
Abstract:
Sensitive assays are needed for the detection of residual viral reservoirs in HIV-1-infected subjects on suppressive combination antiretroviral therapy regimens to determine whether eradication strategies are effective. Mouse viral outgrowth assays have recently been developed and have the potential to be more sensitive than traditional in vitro quantitative viral outgrowth assays. In this article we describe these assays and review several studies that have used them to measure the latent reservoir.
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