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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

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Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
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Detecting Structural Progression in Glaucoma with Optical Coherence Tomography.

Andrew J Tatham1, Felipe A Medeiros2

  • 1Princess Alexandra Eye Pavilion and Department of Ophthalmology, University of Edinburgh, Edinburgh, United Kingdom.

Ophthalmology
|November 22, 2017
PubMed
Summary
This summary is machine-generated.

Optical coherence tomography (OCT) provides objective measurements for glaucoma progression. Recent advancements refine its use, integrating structural data with visual fields for earlier diagnosis and treatment.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Optical coherence tomography (OCT) is widely adopted for objective glaucoma progression assessment.
  • Uncertainty persists regarding OCT's optimal role, including measurement targets and differentiating aging from disease progression.

Purpose of the Study:

  • To review recent developments in OCT for assessing glaucoma progression.
  • To address key questions regarding OCT's application in glaucoma management.

Main Methods:

  • Appraisal of recent studies and developments in OCT technology and application.
  • Focus on Bruch's membrane opening (BMO)-based measurements (BMO-minimum rim width, BMO-minimum rim area).
  • Analysis of macular changes (ganglion cell and inner plexiform layers) and comparison with RNFL measurements.

Main Results:

  • BMO-based measurements offer consistent reference points for structural assessment.
  • Macular and RNFL measurements show varying utility across disease stages.
  • Progressive OCT changes often precede functional loss, indicating clinical relevance and risk stratification.

Conclusions:

  • Optimal glaucoma management integrates OCT imaging with visual fields, leveraging their complementary strengths.
  • OCT findings are clinically relevant, enabling earlier detection of progression and timely treatment adjustments.
  • Further research and consistent application of OCT are crucial for improving glaucoma patient outcomes.