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Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

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Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
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Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
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Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
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Mitral Regurgitation III: Medical Management01:25

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Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
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Related Experiment Video

Updated: Feb 18, 2026

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
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Transcatheter Tricuspid Valve Replacement.

Amar Krishnaswamy1, Jose Navia2, Samir R Kapadia3

  • 1Section of Interventional Cardiology, Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

Interventional Cardiology Clinics
|November 22, 2017
PubMed
Summary

Tricuspid regurgitation (TR) is common and often causes heart failure symptoms. Transcatheter valve procedures may benefit patients with degenerated bioprostheses, while new treatments are emerging for native valve TR.

Keywords:
Transcatheter tricuspid valve replacementTricuspid bioprosthesis degenerationTricuspid regurgitationTricuspid valve

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Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Interventional Cardiology

Background:

  • Tricuspid regurgitation (TR) is a prevalent condition, frequently functional and secondary to right-sided heart dysfunction.
  • TR can lead to significant limitations, including right-sided heart failure symptoms, functional decline, and hospitalizations.
  • Severe TR is associated with poorer survival, though causality is not definitively established.

Purpose of the Study:

  • To review the current understanding and management of tricuspid regurgitation.
  • To discuss the role of transcatheter interventions in specific TR patient populations.
  • To highlight emerging therapeutic strategies for native valve TR.

Main Methods:

  • Literature review of tricuspid regurgitation pathophysiology, clinical impact, and treatment options.
  • Analysis of outcomes for transcatheter valve-in-valve and valve-in-ring procedures in degenerated bioprostheses.
  • Overview of ongoing research and development for novel TR devices.

Main Results:

  • Functional TR is the most common type, linked to other cardiac conditions or pulmonary hypertension.
  • Transcatheter aortic valve prosthesis implantation in a valve-in-valve or valve-in-ring manner can offer symptomatic relief for specific patient groups.
  • Novel device development is underway for treating native tricuspid valve regurgitation.

Conclusions:

  • Tricuspid regurgitation poses significant challenges, impacting patient quality of life and survival.
  • Transcatheter interventions represent a viable option for select patients with degenerated surgical valves.
  • The landscape of TR treatment is evolving with promising new device-based therapies.