Ca2+ leak-What is it? Why should we care? Can it be managed?
Penelope A Boyden1, Godfrey L Smith2
1Department of Pharmacology, Center for Molecular Therapeutics, Columbia University, New York, New York.
Heart Rhythm
|November 22, 2017
Abstract:
For arrhythmia triggers that are secondary to dysfunctional intracellular Ca2+ cycling, there are few, if any, agents that specifically target the Ca2+ handling machinery. However, several candidates have been proposed in the literature. Here we review the idea that these agents or their derivatives will prove invaluable in clinical applications in the future.
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