Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

825
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
825
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

461
Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
461
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

553
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
553
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

1.4K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.4K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.4K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.4K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

460
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
460

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Whole body-MRI identifies widespread, low intensity inflammation in peripheral joints, and axial involvement in a third of patients with early, treatment-naïve, active PsA: data from the GOLMePsA clinical trial.

Rheumatology (Oxford, England)·2026
Same author

Description and therapy of palmoplantar pustular psoriasis under IL-17A or dual IL-17A/F inhibition.

Journal of autoimmunity·2026
Same author

The Role of Musculoskeletal Ultrasound in Psoriatic Arthritis: From Preclinical Detection to Treatment Monitoring.

Current rheumatology reports·2026
Same author

20 years of progress in the classification of immune-mediated diseases.

Nature reviews. Rheumatology·2026
Same author

Two patterns of sacroiliac joint bone marrow oedema are apparent in AxSpA determined by HLA-B27 status, body mass index or psoriasis.

Joint bone spine·2026
Same author

Better communication between rheumatologists and radiologists is key to improving MRI requesting and reporting data in axial spondyloarthritis: audit data from a single specialist centre.

Rheumatology advances in practice·2026

Related Experiment Video

Updated: Feb 18, 2026

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
07:48

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

12.2K

Enthesitis: from pathophysiology to treatment.

Georg Schett1, Rik J Lories2, Maria-Antonietta D'Agostino3

  • 1Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Ulmenweg 18, 91054 Erlangen, Germany.

Nature Reviews. Rheumatology
|November 22, 2017
PubMed
Summary

Enthesitis, inflammation at tendon-bone insertions, is central to psoriatic arthritis. This review details its pathophysiology, clinical features, and cytokine-targeted treatments.

More Related Videos

Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns
08:27

Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns

Published on: December 12, 2025

243
Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice
04:47

Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice

Published on: October 27, 2023

1.8K

Related Experiment Videos

Last Updated: Feb 18, 2026

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
07:48

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

12.2K
Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns
08:27

Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns

Published on: December 12, 2025

243
Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice
04:47

Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice

Published on: October 27, 2023

1.8K

Area of Science:

  • Rheumatology
  • Immunology
  • Pathophysiology

Background:

  • Entheses are crucial for locomotion, connecting tendons/ligaments to bone.
  • Enthesitis is a hallmark of psoriatic arthritis and spondyloarthritis.
  • Current understanding of enthesitis pathophysiology is limited.

Purpose of the Study:

  • To provide insight into the pathophysiology of enthesitis.
  • To discuss clinical features and diagnostic challenges.
  • To review current treatment strategies for enthesitis.

Main Methods:

  • Review of existing literature on enthesitis pathophysiology.
  • Analysis of biomechanical factors, immune cell activation, and cytokine involvement.
  • Summary of clinical manifestations and diagnostic modalities.

Main Results:

  • Initiation involves biomechanics, prostaglandin E2, and innate immunity.
  • IL-23-responsive cells drive inflammation via IL-17A, IL-22, and TNF.
  • Inflammation can lead to new bone formation; clinical detection has limitations.

Conclusions:

  • Understanding enthesitis pathophysiology informs treatment strategies.
  • Cytokine-blocking agents are a key therapeutic approach.
  • Further research is needed to address diagnostic and therapeutic challenges.