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Related Experiment Videos

Factor VII deficiency and pregnancy.

H E Fadel1, J S Krauss

  • 1Department of Obstetrics and Gynecology, School of Medicine, Medical College of Georgia Hospital and Clinics, Augusta.

Obstetrics and Gynecology
|March 1, 1989
PubMed
Summary
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Hereditary factor VII deficiency during pregnancy is rare. Pregnancy may increase factor VII levels even in deficient individuals, requiring fresh frozen plasma for management.

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Reproductive Medicine

Background:

  • Hereditary factor VII deficiency is a rare bleeding disorder.
  • Pregnancy typically elevates factor VII levels, but its effect in deficient individuals is unknown.

Observation:

  • Two cases of factor VII deficiency in pregnancy are presented.
  • Factor VII levels were below 15% in the third trimester and decreased postpartum.

Findings:

  • Pregnancy appears to increase factor VII levels in women with factor VII deficiency.
  • This suggests a physiological response to pregnancy in affected individuals.

Implications:

  • Obstetricians should consider factor VII deficiency with prolonged prothrombin time and normal aPTT.

Related Experiment Videos

  • Fresh frozen plasma is the recommended treatment, potentially used prophylactically in severe cases.