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Published on: February 3, 2023
Optimized furosemide taste masked orally disintegrating tablets
Mohamed Abbas Ibrahim1,2, Amal El Sayeh F Abou El Ela1,3
1Department of Pharmaceutics, College of Pharmacy, King Saud University, Saudi Arabia.
Optimized orally disintegrating tablets (ODTs) for furosemide (FUR) were developed using Eudragit E100 and croscarmellose sodium (CCS). The optimized formulation demonstrated acceptable taste and rapid in vivo disintegration, meeting pharmacopeial standards.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Orally disintegrating tablets (ODTs) offer improved patient compliance for oral drug administration.
- Furosemide (FUR) is a diuretic requiring effective delivery for optimal therapeutic outcomes.
Purpose of the Study:
- To optimize furosemide-loaded orally disintegrating tablets (ODTs) using a 3^2 full factorial design.
- To evaluate the impact of Eudragit E100 (taste masking) and croscarmellose sodium (CCS; superdisintegrant) on ODT properties.
Main Methods:
- Preparation of ODTs containing furosemide via direct compression.
- Optimization using a 3^2 full factorial design with Eudragit E100 (X1) and CCS (X2) as factors.
- Characterization of ODTs for drug content, hardness, friability, wetting time, and dissolution.
Main Results:
- Manufactured ODTs complied with pharmacopeial guidelines for hardness, friability, weight variation, and content.
- Eudragit E100 showed a slight, insignificant effect on disintegration time, while CCS also had an insignificant effect (p > 0.05).
- Eudragit E100 significantly antagonized furosemide dissolution at 30 minutes (p = 0.0004).
Conclusions:
- The optimized ODT formulation exhibited good palatability and an in vivo disintegration time of approximately 10 seconds.
- The study successfully developed furosemide ODTs with acceptable taste and rapid disintegration, meeting quality standards.
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