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Related Experiment Videos

Virilizing serous cystadenoma.

P J Beauchamp1, R S Hughes, W A Schmidt

  • 1Department of Obstetrics, Gynecology, and Reproductive Sciences, Medical School, University of Texas Health Science Center, Houston.

Obstetrics and Gynecology
|March 1, 1989
PubMed
Summary
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A post-menopausal woman experienced virilization due to a rare serous cystadenoma producing excess testosterone. Surgical removal normalized hormone levels, confirming the tumor as the source of androgen excess.

Area of Science:

  • Endocrinology
  • Gynecologic Oncology
  • Pathology

Background:

  • Post-menopausal virilization is rare and requires thorough investigation for androgen-secreting tumors.
  • Elevated testosterone levels in post-menopausal women can indicate an androgen-producing neoplasm.

Observation:

  • A 71-year-old woman presented with symptoms of virilization, including hirsutism and voice changes.
  • Imaging revealed a large right adnexal mass, and hormone studies showed significantly elevated testosterone levels.
  • Intraoperative measurements confirmed high testosterone concentrations in the peripheral and ovarian veins, and within the tumor's cystic fluid.

Findings:

  • Histopathological examination identified the mass as a serous cystadenoma.
  • The tumor was the source of excess testosterone, as evidenced by markedly elevated levels in the right ovarian vein and tumor fluid.

Related Experiment Videos

  • Post-operative testosterone levels normalized rapidly after surgical resection of the cystadenoma.

    • Implications:

    • This case highlights a rare cause of virilization in post-menopausal women, emphasizing the diagnostic importance of hormone evaluation and imaging.
    • Serous cystadenomas, typically benign, can exceptionally function as androgen-secreting tumors.
    • Surgical management is effective in resolving virilization caused by such hormone-producing ovarian neoplasms.