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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Gray matter atrophy patterns in multiple sclerosis: A 10-year source-based morphometry study.

Niels Bergsland1, Dana Horakova2, Michael G Dwyer1

  • 1Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

Neuroimage. Clinical
|November 22, 2017
PubMed
Summary

Gray matter atrophy in specific brain regions is linked to disability progression in multiple sclerosis (MS) patients over 10 years. This study highlights key areas for monitoring MS progression.

Keywords:
AtrophyDisabilityGray matterMRIMultiple sclerosis

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Area of Science:

  • Neuroimaging
  • Neurology
  • Medical Research

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease characterized by inflammation and neurodegeneration.
  • Gray matter (GM) atrophy is a key pathological feature of MS, contributing to disability.
  • Understanding the spatial patterns and temporal evolution of GM atrophy is crucial for predicting disease progression.

Purpose of the Study:

  • To investigate the spatial patterns of gray matter (GM) atrophy in early relapsing-remitting MS.
  • To determine the association between GM atrophy patterns and disability progression over a 10-year follow-up period.
  • To identify specific brain regions where GM atrophy correlates with confirmed disability progression (CDP).

Main Methods:

  • A longitudinal study involving 152 MS patients with 10-year follow-up data.
  • Brain MRI and clinical neurological assessments were utilized.
  • Longitudinal source-based morphometry (SBM) with independent component analysis identified eight spatial GM co-variation patterns.

Main Results:

  • No significant baseline GM volume differences were found between patients with and without CDP.
  • Patients with CDP showed a significantly greater rate of GM atrophy in two specific patterns over 10 years (corrected p=0.001 and p=0.007).
  • The identified patterns of GM atrophy associated with CDP involved regions critical for motor and cognitive functions, including learning and memory.

Conclusions:

  • Source-based morphometry (SBM) provides a novel approach to analyze the temporal dynamics of regional GM atrophy.
  • Disability progression in MS over a decade is significantly associated with GM atrophy in motor and cognitive-related brain areas.
  • These findings underscore the importance of monitoring GM atrophy in specific functional networks for predicting MS outcomes.