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Evaluation of the associations between endothelial dysfunction, inflammation and coagulation in Crimean-Congo

Halef Okan Doğan1, Seyit Ali Büyüktuna2, Sercan Kapancik3

  • 1Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey. halefokan@gmail.com.

Archives of Virology
|November 22, 2017
PubMed

Insights

Crimean-Congo hemorrhagic fever (CCHF) is linked to inflammation and coagulation issues. Endothelial dysfunction plays a key role in CCHF, with serum endocan potentially serving as a biomarker.

Area of Science:

  • Infectious Diseases
  • Hematology
  • Vascular Biology

Background:

  • Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne zoonotic viral illness.
  • Understanding the interplay between inflammation, coagulation, and endothelial dysfunction in CCHF is crucial for patient management.

Purpose of the Study:

  • To investigate the association between inflammation, coagulation parameters, and endothelial dysfunction in patients with CCHF.
  • To evaluate the potential of serum endocan as a biomarker for endothelial dysfunction in CCHF.

Main Methods:

  • A case-control study involving 40 CCHF patients and 50 healthy controls.
  • Analysis of serum markers including alanine aminotransferase (ALT), aspartate aminotransferase (AST), endocan, high-sensitivity C-reactive protein (hsCRP), international normalized ratio (INR), prothrombin time (PT), activated partial thromboplastin time (aPTT), and platelet count.

Main Results:

  • CCHF patients showed significantly higher levels of hsCRP, ALT, AST, and aPTT compared to controls.
  • Conversely, CCHF patients exhibited lower median endocan and platelet concentrations.
  • Serum hsCRP positively correlated with PT, aPTT, and INR, but serum endocan did not correlate with these coagulation markers.

Conclusions:

  • Endothelial dysfunction is a critical aspect of CCHF pathogenesis, and serum endocan may indicate its severity.
  • Inflammation and endothelial dysfunction appear to be independent in CCHF, while coagulation abnormalities may stem from impaired liver function.
  • Elevated hsCRP might play a compensatory role in hemostasis, warranting further investigation.

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