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Advanced Strategies for Eliminating the cccDNA of HBV

Jingwu Dong1, Jie Ying2, Xiaoyan Qiu2

  • 1Department of Gastroenterology, Xuyi People's Hospital, 28 Hongwu Road, Xuyi, 211700, Jiangsu, People's Republic of China.

Digestive Diseases and Sciences
|November 22, 2017
PubMed

Insights

Eliminating covalently closed circular DNA (cccDNA) from hepatocytes is key to curing persistent hepatitis B virus (HBV) infection. This review explores current and future strategies for HBV cccDNA clearance.

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Persistent hepatitis B virus (HBV) infection is linked to hepatocyte cccDNA episomes.
  • cccDNA levels correlate with HBeAg status, being higher in HBeAg-positive patients.
  • Trace cccDNA can persist even after HBV infection resolution.

Purpose of the Study:

  • To review recent strategies aimed at eliminating HBV cccDNA.
  • To discuss future therapeutic developments for chronic hepatitis B.

Main Methods:

  • Literature review of studies on HBV cccDNA elimination strategies.
  • Analysis of current and emerging treatment approaches for chronic hepatitis B.

Main Results:

  • cccDNA presence is a hallmark of persistent HBV infection.
  • cccDNA clearance represents a potential curative approach for HBV.
  • Various strategies are being investigated for cccDNA elimination.

Conclusions:

  • Effective clearance of HBV cccDNA is crucial for a definitive cure.
  • Ongoing research focuses on developing novel treatments to eradicate cccDNA.
  • Future therapies aim to achieve complete viral clearance in chronic hepatitis B patients.

Keywords:
Chronic hepatitis B therapyHBV infectionStrategycccDNA

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