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Renal hypoxia in kidney disease: Cause or consequence?
C P C Ow1, J P Ngo1, M M Ullah1
1Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Physiology, Monash University, Melbourne, Vic., Australia.
Acta Physiologica (Oxford, England)
|November 22, 2017
Summary
Tissue hypoxia is common in chronic kidney disease (CKD) and acute kidney injury (AKI). While it drives damage, its role as a common pathway needs further testing.
Area of Science:
- Nephrology
- Pathophysiology
- Hypoxia Research
Background:
- Tissue hypoxia is implicated in chronic kidney disease (CKD) and acute kidney injury (AKI) pathophysiology.
- It may initiate a cycle of tubular injury, vascular rarefaction, fibrosis, and worsening hypoxia.
Purpose of the Study:
- To critically evaluate the role of tissue hypoxia in kidney disease.
- To systematically review literature addressing six key questions regarding hypoxia and kidney pathology.
Main Methods:
- Systematic literature review.
- Evaluation of existing evidence concerning tissue hypoxia in AKI and CKD.
Main Results:
- Tissue hypoxia is a frequent feature in both AKI and CKD.
- Renal tissue hypoxia drives signaling cascades leading to damage and dysfunction (in vitro).
- Hypoxia can independently cause renal pathology and may precede it in some cases.
Conclusions:
- The hypothesis of tissue hypoxia as a common pathway for AKI and CKD remains inadequately tested.
- Further research is needed on hypoxia-pathology colocalization and the efficacy of hypoxia-targeted therapies.
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