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TDP2, TOP2, and SUMO: what is ZATT about?
Guido Zagnoli-Vieira1, Keith W Caldecott1
1Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, BN1 9RQ, United Kingdom.
Abstract:
Recently, ZATT (also known as ZNF451 or Zpf451) was reported by Schellenberg et al. to aid the removal of Topoisomerase II cleavage complexes by stimulating the phosphodiesterase activity of Tyrosyl DNA Phosphodiesterase 2. Although the full implication of this discovery is unknown, it will help us understand how cells respond to topoisomerase-induced genome damage and chemotherapeutic topoisomerase 'poisons'.
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