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Updated: Feb 18, 2026
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease
Matheus Barbosa de Miranda1, Adriene Siqueira de Melo2, Mariana Silva Almeida1
1Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, Brasil.
Introduction:
Elucidating the molecules involved in the inflammatory process of chronic Chagas disease may allow identification of treatment targets.
Methods:
The ex vivo phenotypic expression of chemokine receptors CCR1, CCR3, CCR4, CCR5, CXCR2, CXCR3, CXCR4, and CXCR5 on the CD4+ and CD8+ T-cells of patients with chronic Chagas cardiomyopathy of varying severity was evaluated using flow cytometry.
Results:
Differential expression of CD4+CCR3+ and CD8+CCR4+ T-cells was observed in patients with mild cardiac involvement compared, respectively, with patients with severe cardiac and asymptomatic forms of Chagas disease.
Conclusions:
These receptors are possibly involved in the pathogenesis of chronic Chagas cardiomyopathy.
