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Percutaneously placed endovascular grafts for aortic aneurysms: feasibility study
D Mirich1, K C Wright, S Wallace
1Department of Diagnostic Radiology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Radiology
|March 1, 1989
Summary
This study explored a new transcatheter endoprosthesis for treating aortic aneurysms in dogs. The device showed promise in restoring aortic flow and preserving side branches, though one case highlighted potential complications.
Area of Science:
- Vascular Surgery
- Biomedical Engineering
- Interventional Cardiology
Background:
- Aortic aneurysms pose significant risks, necessitating innovative treatment options.
- Transcatheter endoprostheses offer a less invasive approach compared to open surgery.
- The feasibility of novel endovascular devices requires thorough investigation.
Purpose of the Study:
- To evaluate the feasibility of a new transcatheter endoprosthesis for treating experimental aortic aneurysms.
- To assess the short-term efficacy and safety of this novel device in a canine model.
Main Methods:
- Experimental aortic aneurysms were created in six dogs.
- Aortic aneurysms were treated using nylon-covered, self-expanding metallic stents (endoprostheses).
- Follow-up extended up to 7 months to assess graft performance and complications.
Main Results:
- The endoprosthesis successfully reconstituted the aortic lumen and excluded aneurysms in most cases.
- Neointimal encasement of the nylon material formed a new vascular lumen, preserving side branch patency.
- One instance of incomplete graft expansion led to thrombus formation and renal artery occlusion.
Conclusions:
- The transcatheter endoprosthesis demonstrates feasibility for aneurysm treatment, with potential for neointimal healing and preservation of visceral blood supply.
- Careful graft deployment and material selection are crucial to avoid complications like incomplete expansion and thrombosis.