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Related Concept Videos

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The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
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Related Experiment Video

Updated: Feb 18, 2026

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
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Mechanical colon cleansing for screening colonoscopy: A randomized controlled trial.

Kamran Ayub1, Gyanprakash Ketwaroo2, Suhaib Abudayyeh3

  • 1Department of Medicine, Silver Cross Hospital, New Lenox, Illinois, USA.

Journal of Digestive Diseases
|November 22, 2017
PubMed
Summary

Pulsed irrigation evacuation (PIE) and sodium phosphate offer superior colon cleansing compared to polyethylene glycol (PEG). PIE is recommended for patients at high risk of inadequate preparation.

Keywords:
clinical trialcolonoscopypolyethylene glycolpulsed irrigated evacuationsodium phosphate

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Area of Science:

  • Gastroenterology
  • Endoscopy
  • Colorectal Cancer Screening

Background:

  • Effective colonoscopy relies on high-quality bowel preparation.
  • Inadequate preparation can lead to missed lesions and repeat procedures.

Purpose of the Study:

  • To compare the efficacy and tolerability of pulsed irrigation evacuation (PIE), polyethylene glycol (PEG), and sodium phosphate for colon preparation.

Main Methods:

  • A randomized trial involving 391 outpatients comparing PIE, PEG (4L), and sodium phosphate (90 mL) with water.
  • Colon cleansing was blindly assessed using a 5-point scale (0=very poor, 4=excellent).

Main Results:

  • PIE and sodium phosphate demonstrated superior cleansing (median score 4) versus PEG (median score 3).
  • Inadequate preparations occurred more frequently with PEG (18%) than PIE (5%).
  • Vomiting was significantly higher with sodium phosphate (37%) compared to PEG (5%) and PIE (2%).

Conclusions:

  • Pulsed irrigation evacuation (PIE) and sodium phosphate are more effective than polyethylene glycol for colon preparation.
  • PIE is the preferred method for patients at high risk of inadequate preparation or those with prior unsatisfactory results.