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Enterococcal bacteremia: analysis of 75 episodes.

R M Gullberg1, S R Homann, J P Phair

  • 1Section of Infectious Disease, Northwestern University Medical School, Chicago, Illinois 60611.

Reviews of Infectious Diseases
|January 1, 1989
PubMed
Summary

Enterococcal bacteremia, often occurring in seriously ill patients, shows high survival rates even without antibiotics. Treatment for enterococcal infections should be individualized, as two-drug regimens are not always necessary.

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Area of Science:

  • Infectious Diseases
  • Internal Medicine
  • Clinical Microbiology

Background:

  • Enterococcal bacteremia is a significant cause of hospital-acquired infections.
  • Patients often present with severe underlying conditions, complicating treatment and prognosis.
  • The emergence of antibiotic resistance necessitates a re-evaluation of treatment strategies.

Purpose of the Study:

  • To retrospectively analyze the clinical characteristics and outcomes of enterococcal bacteremia.
  • To evaluate the effectiveness of different antibiotic treatment regimens.
  • To determine factors influencing mortality and treatment response in patients with enterococcal bacteremia.

Main Methods:

  • Retrospective analysis of 75 cases of enterococcal bacteremia.

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  • Review of patient demographics, underlying diseases, and clinical course.
  • Assessment of antibiotic therapies, including single-drug, two-drug, and no-therapy groups.

    • Main Results:

    • Most patients had serious underlying diseases, with bacteremia developing late after admission.
    • Mortality was 30%, with 12% of deaths directly attributed to enterococcal bacteremia.
    • High response rates were observed across all treatment groups, including those receiving no antibiotics, suggesting tailored therapy is effective.

    Conclusions:

    • Enterococcal bacteremia outcomes can be favorable, even in complex cases.
    • Aggressive multi-drug therapy is not consistently superior and individualized treatment plans are crucial.
    • Further research into optimal, tailored treatment strategies for enterococcal bacteremia is warranted.