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Neonatal meningitis due to Streptococcus mitis.

G E Bignardi1, D Isaacs

  • 1Department of Microbiology, John Radcliffe Hospital, Oxford, United Kingdom.

Reviews of Infectious Diseases
|January 1, 1989
PubMed
Summary
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Streptococcus mitis meningitis is rare in infants. This case highlights successful treatment with penicillin and netilmicin for a penicillin-tolerant S. mitis strain.

Area of Science:

  • Neonatal infectious diseases
  • Microbiology
  • Pediatric neurology

Background:

  • Bacterial meningitis remains a significant cause of neonatal morbidity and mortality.
  • Streptococcus mitis, a member of the viridans group streptococci, is typically considered a commensal organism.
  • While other streptococcal species are known pathogens, S. mitis is an uncommon cause of invasive infections, particularly in neonates.

Observation:

  • A neonate presented with symptoms of illness two days post-normal delivery.
  • Cerebrospinal fluid analysis identified Streptococcus mitis as the causative agent.
  • In vitro testing revealed penicillin tolerance of the isolated S. mitis strain.

Findings:

  • The infant received a treatment regimen including penicillin and netilmicin for the initial two days.

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  • Clinical recovery was uneventful following the antibiotic intervention.
  • This case adds to the limited number of documented instances of S. mitis meningitis in infants.

    • Implications:

    • This case underscores the importance of considering less common pathogens in neonatal meningitis.
    • Effective treatment strategies may involve combination antibiotic therapy, even for penicillin-tolerant organisms.
    • Further research into the pathogenicity and treatment of S. mitis infections in neonates is warranted.