Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.6K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.4K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.4K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

4.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.8K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

3.4K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.4K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

3.2K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early Mechanical Dissociation of Helical Blade-Barrel Interface in Proximal Femoral Nail: A Case Report.

Journal of orthopaedic case reports·2026
Same author

The case for an integrated biobanking initiative in South Asia.

The Lancet regional health. Southeast Asia·2026
Same author

Immunomodulatory Roles of Probiotics: From Intestinal Barrier Regulation to Clinical Applications.

Current pharmaceutical biotechnology·2026
Same author

Oropouche virus: transmission, epidemiology, genetic diversity, and public health implications.

EClinicalMedicine·2026
Same author

Revisiting BCG revaccination: Hopes, evidence, and the emerging verdict.

The National medical journal of India·2026
Same author

Potential Effect of Belladonna in the Management of Convulsions in Zebrafish (<i>Danio rerio</i>) and In Silico Mechanistic Approach.

Annals of neurosciences·2026

Related Experiment Video

Updated: Feb 18, 2026

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

12.3K

Mitochondrial Dysfunction Linking Obesity and Asthma.

Naveen K Bhatraju1, Anurag Agrawal1,2,3

  • 11 CSIR Institute of Genomics and Integrative Biology, Delhi, India.

Annals of the American Thoracic Society
|November 22, 2017
PubMed
Summary
This summary is machine-generated.

Mitochondrial dysfunction links obesity and asthma, impacting cellular pathways. Targeting mitochondria may offer new treatments for these widespread conditions.

Keywords:
asthmadiabeteslungmetabolic syndromemitochondria

More Related Videos

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

14.8K
Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases
08:12

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Published on: October 4, 2024

2.3K

Related Experiment Videos

Last Updated: Feb 18, 2026

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

12.3K
Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

14.8K
Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases
08:12

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Published on: October 4, 2024

2.3K

Area of Science:

  • Cellular Biology
  • Metabolic Disorders
  • Respiratory Medicine

Background:

  • Obesity and asthma share bidirectional epidemiological links.
  • Mitochondria play crucial roles in cellular metabolism, stress response, and cytotoxicity.
  • Mitochondrial dysfunction is a recognized feature of obesity and is increasingly linked to asthma.

Purpose of the Study:

  • To explore the intersection of pathophysiological pathways in obesity and asthma at the mitochondrial level.
  • To review evidence connecting mitochondrial dysfunction to asthma development and severity.
  • To discuss the therapeutic potential of mitochondria-targeted strategies for both conditions.

Main Methods:

  • Review of experimental evidence linking mitochondrial dysfunction to asthma.
  • Analysis of the role of mitochondria in airway remodeling.
  • Clinical relevance assessment for the obese-asthma phenotype.

Main Results:

  • Asthma is associated with aberrant mitochondrial metabolism and dysfunction.
  • Mitochondrial dysfunction can induce asthma-like features or worsen asthma severity.
  • Mitochondrial dysfunction in airway cells triggers airway remodeling independently of inflammation.

Conclusions:

  • Mitochondrial dysfunction is a common factor in obesity and asthma epidemics.
  • Environmental and lifestyle factors may initiate mitochondrial dysfunction, increasing disease risk.
  • Mitochondrial health-focused strategies are promising for preventing and treating obesity and asthma.