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Culturing and Maintaining Clostridium difficile in an Anaerobic Environment
Published on: September 14, 2013
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Clostridium Difficile Infection in the Nephrology Ward
Kidney & Blood Pressure Research
|November 22, 2017
Summary
Clostridium difficile infection (CDI) is a growing concern, especially in chronic kidney disease patients. Lactobacillus plantarum 299v shows promise in preventing CDI in hospitalized nephrology patients.
Area of Science:
- Infectious Diseases
- Nephrology
- Microbiology
Background:
- Clostridium difficile infection (CDI) is a leading cause of nosocomial diarrhea, with increasing incidence, severity, and mortality.
- Risk factors for CDI include antibiotic therapy, hospitalization, and comorbidities, with a heightened risk observed in chronic kidney disease (CKD) patients.
- CKD patients face increased CDI risk due to frequent antibiotic use, hospitalizations, older age, and compromised immunity, leading to gut dysbiosis.
Purpose of the Study:
- To evaluate the efficacy of Lactobacillus plantarum 299v in preventing Clostridium difficile infection (CDI) in hospitalized patients with chronic kidney disease.
- To assess the impact of Lactobacillus plantarum 299v on CDI incidence within a nephrology ward setting.
Main Methods:
- A meta-analysis of clinical studies, including observational, cohort, and case-control designs, was conducted.
- The study specifically examined data from patients hospitalized in a nephrology ward where Lactobacillus plantarum 299v was used for CDI prophylaxis.
Main Results:
- Meta-analyses revealed a significantly higher risk of CDI and CDI recurrence in patients with chronic kidney disease.
- A highly significant reduction in CDI incidence was observed in patients hospitalized in a nephrology ward after the introduction of Lactobacillus plantarum 299v prophylaxis.
- CKD patients with CDI exhibited an increased mortality risk compared to those without CDI.
Conclusions:
- Lactobacillus plantarum 299v demonstrates potential as a promising preventive measure against CDI in chronic kidney disease patients.
- Targeted probiotic intervention, such as Lactobacillus plantarum 299v, may be beneficial for reducing CDI incidence in vulnerable hospitalized populations like those in nephrology wards.
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