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Related Concept Videos

Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
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Positive Regulator Molecules02:39

Positive Regulator Molecules

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Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
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Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
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Cancer Cell Controller.

Sunil Kumar Kashyap1, Vikas Kumar Jain2, Swati Jain3

  • 1Department of Mathematics, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, India.

Journal of Experimental Therapeutics & Oncology
|November 22, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces a novel controller designed to manage uncontrolled cell growth, a hallmark of cancer. Algebraic structures are employed to analyze and understand cancer cell behavior for improved therapeutic strategies.

Keywords:
Algebraic Structures.CancerCellController

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Area of Science:

  • Oncology
  • Control Theory
  • Computational Biology

Background:

  • Cancer is characterized by uncontrolled cellular proliferation.
  • Existing therapeutic strategies face challenges in precisely targeting cancer cells.
  • Mathematical modeling offers potential for understanding and controlling cancer progression.

Purpose of the Study:

  • To present a novel controller for managing uncontrolled cancer cell growth.
  • To investigate the application of algebraic structures in cancer cell analysis.
  • To provide a framework for developing targeted cancer therapies.

Main Methods:

  • Review of cancer cell characteristics using algebraic structures.
  • Development of a control system for cellular regulation.
  • Simulation and analysis of controller performance in silico.

Main Results:

  • Demonstration of a controller capable of influencing cancer cell behavior.
  • Identification of specific algebraic properties relevant to cancer cell control.
  • Potential for improved therapeutic outcomes through controlled cellular processes.

Conclusions:

  • Algebraic structures provide a viable mathematical framework for cancer cell control.
  • The developed controller shows promise for future cancer treatment applications.
  • Further research is warranted to translate these findings into clinical practice.