Related Experiment Video
Updated: Feb 18, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
Published on: September 27, 2012
Modeling transcriptional co-regulation of mammalian circadian clock
Yanqin Wang1, Xin Ni1, Jie Yan1
1School of Mathematical Sciences, Soochow University, Suzhou 215006, Jiangsu, China
Abstract:
The circadian clock is a self-sustaining oscillator that has a period of about 24 hours at the molecular level. The oscillator is a transcription-translation feedback loop system composed of several genes. In this paper, a scalar nonlinear differential equation with two delays, modeling the transcriptional co-regulation in mammalian circadian clock, is proposed and analyzed. Sufficient conditions are established for the asymptotic stability of the unique nontrivial positive equilibrium point of the model by studying an exponential polynomial characteristic equation with delay-dependent coefficients. The existence of the Hopf bifurcations can be also obtained. Numerical simulations of the model with proper parameter values coincide with the theoretical result.
More Related Videos
Related Concept Videos
Circadian Rhythms and Gene Regulation
Co-activators and Co-repressors
Co-activators and Co-repressors
Master Transcription Regulators
Master Transcription Regulators
Biological Clocks and Seasonal Responses

