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Updated: Feb 18, 2026

Direct Induction of Human Neural Stem Cells from Peripheral Blood Hematopoietic Progenitor Cells
Published on: January 28, 2015
An alternative method for custom prime: A case report of successful peripheral blood stem cell harvesting from two
Ashraf Malek Mohammadi1, Amir Hossein Norooznezhad1, Parivash Aminian1
1Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Insights
Allogeneic peripheral blood stem cell (APBSC) transplantation from low-weight child donors is feasible and effective for treating hematological malignancies. Promising results were observed in two pediatric cases, demonstrating successful engraftment and transplantation.
Area of Science:
- Hematology
- Pediatric Oncology
- Stem Cell Transplantation
Background:
- Allogeneic peripheral blood stem cell (APBSC) transplantation is a crucial therapy for hematological malignancies.
- Challenges exist in utilizing stem cells from low-weight pediatric donors due to potential complications.
Abstract:
Allogeneic peripheral blood stem cell (APBSCs) transplantation is an effective treatment for hematological malignancies. However low-weight donor children meet some complications. In the current report, PBSCs were harvested from a 14-month-old child (9.8Kg) for a 6years old sibling recipient suffering from pre-B type of acute lymphoblastic leukemia (ALL) and also 24 months old male child donor (12Kg) for a haploidentical recipient suffering from acute myeloid leukemia (AML-M4EO). The PBSC harvesting was performed using Spectra™ Optia® apheresis software with continuous mononuclear cell (CMNC) procedure. The results were completely promising and both recipients underwent an acceptable transplantation.
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