Related Experiment Video
Updated: Feb 18, 2026
10:07
Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
Published on: October 8, 2021
1.8K
Selective incorporation of foreign functionality into fibrin gels through a chemically modified DNA aptamer
Hiroto Fujita1, Yusuke Inoue1, Masayasu Kuwahara1
1Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan.
Bioorganic & Medicinal Chemistry Letters
|November 23, 2017
Abstract:
We found for the first time that a thrombin-binding DNA aptamer (TBA) is selectively entrapped in fibrin gels during the gel growth reaction catalyzed by thrombin. Furthermore, using this phenomenon, we successfully demonstrated multiple incorporation of amphiphilic aliphatic groups into fibrin gels via chemically modified TBA.
