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Metallothionein-I accumulation in the rat lung following a single paraquat administration
1Division of Environmental Pollution Research, Fukushima Medical College, Japan.
Toxicology Letters
|January 1, 1989
Abstract:
The ability of paraquat (PQ), a free radical inducible chemical, to increase metallothionein-I (MT-I) content in the tissues was determined using radioimmunoassay. A single dose of PQ into the rat caused a sevenfold increase in pulmonary MT-I concentration on day 1 and its concentration returned to the control level by day 5. Paraquat-induced increase in MT-I was not observed in the kidney, but was seen in the liver. The data show the difference in accumulation of MT-I in liver, kidney and lung after intraperitoneal injection of a high dose of PQ.