Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanisms restricting hepatitis B virus cross-species transmission.

mBio·2026
Same author

Metadomain and metaloop genome interactions in mammalian T cells.

Cell reports·2026
Same author

EIF4H and YBX1 are essential host factors for hepatitis E virus replication and pathogenesis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Metadomain and metaloop genome interactions in mammalian T cells.

bioRxiv : the preprint server for biology·2025
Same author

Receptor transporter protein 4 (RTP4)-mediated repression of hepatitis C virus replication in mouse cells.

PLoS pathogens·2025
Same author

Assessment of hepatitis C virus permissiveness in iteratively genetically humanized mice.

Journal of virology·2025
Same journal

Engineering immune cell therapies for inflammatory bowel disease: from stem cells to CAR T cells.

Nature reviews. Gastroenterology & hepatology·2026
Same journal

Actin cytoskeletal dynamics in hepatic myofibroblasts and fibrosis.

Nature reviews. Gastroenterology & hepatology·2026
Same journal

Synthetic data generation: challenges and perspectives for gastrointestinal medicine.

Nature reviews. Gastroenterology & hepatology·2026
Same journal

Steatotic liver disease in Latin America: current views and perspectives.

Nature reviews. Gastroenterology & hepatology·2026
Same journal

Positive results for daraxonrasib for previously treated metastatic pancreatic cancer.

Nature reviews. Gastroenterology & hepatology·2026
Same journal

Dietary perturbation and microbial adaptation in the gut.

Nature reviews. Gastroenterology & hepatology·2026
See all related articles

Related Experiment Video

Updated: Feb 18, 2026

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
04:11

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

Published on: December 15, 2023

4.8K

Hepatitis E virus: advances and challenges.

Ila Nimgaonkar1, Qiang Ding1, Robert E Schwartz2

  • 1Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, New Jersey 08544, USA.

Nature Reviews. Gastroenterology & Hepatology
|November 23, 2017
PubMed
Summary
This summary is machine-generated.

Hepatitis E virus (HEV) causes millions of infections and deaths globally. This review updates HEV

More Related Videos

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

10.3K
Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
09:35

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

14.0K

Related Experiment Videos

Last Updated: Feb 18, 2026

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
04:11

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

Published on: December 15, 2023

4.8K
A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

10.3K
Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
09:35

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

14.0K

Area of Science:

  • * Virology and Hepatology: Focus on the Hepatitis E virus (HEV).

Background:

  • * Hepatitis E virus (HEV) causes significant global morbidity and mortality, with over 20 million infections annually.
  • * While often self-limiting, HEV poses severe risks to pregnant women and immunocompromised individuals, and is increasingly reported in industrialized nations.
  • * Current challenges include limited treatment options, a vaccine only licensed in China, and a scarcity of experimental platforms for research.

Purpose of the Study:

  • * To provide an updated overview of the Hepatitis E virus (HEV) life cycle.
  • * To discuss current cell culture and animal models for HEV research.
  • * To highlight emerging experimental platforms for studying HEV and other hepatotropic viruses.

Main Methods:

  • * Comprehensive literature review of HEV biology, transmission, and pathogenesis.
  • * Analysis of existing and emerging experimental models, including cell culture and animal models.
  • * Synthesis of current knowledge on HEV life cycle and research platforms.

Main Results:

  • * HEV infections are a growing global health concern, with diverse transmission routes including zoonotic and iatrogenic.
  • * Significant knowledge gaps persist due to limitations in experimental models, hindering research and therapeutic development.
  • * Emerging platforms show promise for advancing the understanding of HEV and related viral pathogens.

Conclusions:

  • * Further research into HEV biology and pathogenesis is crucial for developing effective treatments and control strategies.
  • * Development and validation of robust experimental platforms are essential to overcome current research limitations.
  • * Enhanced understanding of HEV is critical for public health, particularly in vulnerable populations and industrialized countries.