Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute nephropathy in young lambs.

K W Angus1, J C Hodgson, B D Hosie

  • 1Moredun Research Institute, Edinburgh.

The Veterinary Record
|January 7, 1989
PubMed
Summary

Acute renal failure in lambs causes nearly 100% mortality. This study identified nephrosis and toxic tubular necrosis as key pathologies, highlighting significant plasma biochemical changes in affected young sheep.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Mixed-methods Study of How to Improve Primary-secondary Transitions in England: Combining Academic Research with Policy and Practice Consultation.

Educational psychology review·2026
Same author

Extracting Abscessed Teeth.

The Dental register·2021
Same author

Preliminary survey of lamb losses (black loss) in Highland sheep flocks.

The Veterinary record·2016
Same author

Differences in Virulence Between Bovine-Derived Clinical Isolates of Pasteurella multocida Serotype A from the UK and the USA in a Model of Bovine Pneumonic Pasteurellosis.

Journal of comparative pathology·2016
Same author

An analysis of cattle farmers' perceptions of drivers and barriers to on-farm control of Escherichia coli O157.

Epidemiology and infection·2014
Same author

High prevalence of paratuberculosis in rabbits is associated with difficulties in controlling the disease in cattle.

Veterinary journal (London, England : 1997)·2013

Area of Science:

  • Veterinary Pathology
  • Sheep Medicine
  • Renal Physiology

Background:

  • Acute renal failure (ARF) is a significant cause of mortality in young lambs.
  • Previous studies have indicated various potential causes, but a comprehensive overview of pathological findings and biochemical changes is lacking.

Purpose of the Study:

  • To diagnose and characterize acute renal failure in lambs.
  • To investigate the pathological and biochemical profiles associated with ARF in affected lambs.
  • To identify risk factors and potential causes of ARF in different geographical regions.

Main Methods:

  • Clinical examination, necropsy, and histological evaluation of affected lambs from 39 flocks.
  • Biochemical analysis of plasma samples from clinically affected lambs and in-contact healthy controls.

Related Experiment Videos

  • Correlation of pathological findings with clinical signs and biochemical alterations.

    • Main Results:

    • ARF was diagnosed in 39 flocks, with mortality approaching 100% in clinically affected lambs.
    • Nephrosis (83%) and toxic tubular necrosis were the primary histological findings.
    • Affected lambs exhibited azotaemia, haemoconcentration, proteinuria, and significant alterations in plasma urea, creatinine, protein, phosphorus, and calcium levels.

    Conclusions:

    • Acute renal failure in lambs is characterized by high mortality and specific pathological lesions, primarily nephrosis.
    • Distinctive plasma biochemical changes, including elevated urea and creatinine and altered calcium-phosphorus balance, are indicative of ARF in lambs.
    • Further research is needed to elucidate the specific etiological agents and environmental factors contributing to ARF in different sheep farming systems.