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Urate-Lowering Therapy Ameliorates Kidney Function in Type 2 Diabetes Patients With Hyperuricemia
1Ueno Internal Medicine and Diabetes Clinic, Hortensia Building 5F, Motomachi-dori, Chuo-ku, Kobe, Hyogo 650-0022, Japan.
Journal of Clinical Medicine Research
|November 23, 2017
Summary
Lowering serum urate in type 2 diabetic patients significantly improved kidney function (eGFR) for 52 weeks. This urate-lowering therapy may slow diabetic nephropathy progression.
Area of Science:
- Nephrology
- Endocrinology
- Pharmacology
Background:
- Hyperuricemia contributes to kidney dysfunction and diabetic nephropathy progression.
- A vicious cycle exists between increased serum urate and kidney damage.
- Urate-lowering therapy is explored for its impact on diabetic nephropathy.
Purpose of the Study:
- To evaluate the efficacy of urate-lowering therapy in type 2 diabetic patients with hyperuricemia.
- To assess the impact of reduced serum urate on kidney function and markers of nephropathy.
Main Methods:
- 34 type 2 diabetic patients with hyperuricemia received urate-lowering drugs for 52 weeks.
- Key parameters monitored included serum urate, eGFR, blood pressure, HbA1c, and UACR.
- Comparisons were made between baseline and endpoint/52-week measurements.
Main Results:
- Serum urate levels were consistently maintained below 6.0 mg/dL.
- Significant improvements in estimated glomerular filtration rate (eGFR) were observed.
- Urinary albumin-to-creatinine ratio (UACR) decreased in patients without microalbuminuria.
Conclusions:
- Lowering serum urate to below 6.0 mg/dL significantly improves kidney function in type 2 diabetics with hyperuricemia.
- The beneficial effects on kidney function were sustained for at least 52 weeks.
- Urate-lowering therapy presents a potential strategy to mitigate diabetic nephropathy progression.
Keywords:
Diabetic nephropathyEstimated glomerular filtration rateHyperuricemiaType 2 diabetesUrinary albumin-to-creatinine ratioMore Related Videos
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