Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

27
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
27
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.0K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intra-Rater, Inter-Rater, and Test-Retest Reliability of a Laser- and Inclinometer-Based Hip Joint Position Sense Test in Healthy Adults: A Two-Phase Study with Preliminary Reference Values.

Muscles (Basel, Switzerland)·2026
Same author

CDO1 is a new biomarker to discriminate aggressive forms of prostate cancer.

Oncogene·2026
Same author

Computer-Aided Quantitative Image Analysis of Multiple Human Epidermal Growth Factor Receptor 2 Immunohistochemistry Assays in Breast Carcinoma.

Archives of pathology & laboratory medicine·2026
Same author

Genetic diversity of alpha and betacoronaviruses in cave and temple-roosting bats in Vientiane Province, Lao PDR.

PloS one·2026
Same author

What is the clinical utility of histological diagnosis between pilomatricoma and trichilemmal cyst in children?

La Pediatria medica e chirurgica : Medical and surgical pediatrics·2025
Same author

StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models.

Cell·2025

Related Experiment Video

Updated: Feb 18, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

12.0K

Multivalent cationic pseudopeptide polyplexes as a tool for cancer therapy.

Zoi Diamantopoulou1, Maud-Emmanuelle Gilles1, Maha Sader1

  • 1Laboratory of Growth, Reparation and Tissue Regeneration (CRRET), University of Paris Est, ERL-CNRS 9215, 94010 Créteil, France.

Oncotarget
|November 23, 2017
PubMed
Summary

Novel N6L nanoparticles show potent anticancer effects against pancreatic cancer models. These polyplex nanoparticles enhance drug delivery and efficacy, outperforming gemcitabine in aggressive models.

Keywords:
antitumour activitynanoparticlesnucleolinpancreatic ductal adenocarcinomapolyplex

More Related Videos

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.9K

Related Experiment Videos

Last Updated: Feb 18, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

12.0K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.9K

Area of Science:

  • Biotechnology
  • Nanomedicine
  • Oncology

Background:

  • Pancreatic cancer remains a challenging disease with limited effective treatments.
  • Developing novel drug delivery systems is crucial for improving therapeutic outcomes.
  • Pseudopeptide N6L shows antitumour potential but requires enhanced delivery.

Purpose of the Study:

  • To develop and evaluate novel polyplex nanoparticles for enhanced anticancer therapy.
  • To investigate the mechanism of action and efficacy of N6L-polyplexes in pancreatic cancer models.
  • To compare the efficacy of N6L-polyplexes with gemcitabine in aggressive pancreatic cancer.

Main Methods:

  • Formulation of polyplex nanoparticles by mixing polyelectrolytes and N6L pseudopeptide.
  • In vivo evaluation using pancreatic cancer models (PANC-1 and mPDAC cells).
  • Mechanism of action studies using affinity isolation and si-RNA; biodistribution studies in mice.

Main Results:

  • N6L incorporation into polyplex nanoparticles significantly enhanced antitumour activity.
  • N6L-polyplexes are internalized via interaction with nucleolin.
  • N6L-polyplexes demonstrated superior efficacy compared to gemcitabine in aggressive pancreatic cancer models.
  • Biodistribution studies confirmed tumor-specific localization of N6L-polyplexes.

Conclusions:

  • N6L-polyplex nanoparticles represent a promising strategy for pancreatic cancer treatment.
  • This novel nanomedicine approach enhances drug delivery and efficacy.
  • N6L nanoparticles offer a potential therapeutic option for hard-to-treat pancreatic cancers.