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Late ventricular potentials in familial Mediterranean fever with and without AA amyloidosis

Udi Nussinovitch1, Avi Livneh2,3

  • 1Medicine A, Rambam Health Care Campus, Haalia Hashnia, Haifa, Israel.

European Journal of Rheumatology
|November 23, 2017
PubMed
Abstract

Insights

Familial Mediterranean fever (FMF) patients, even those with amyloidosis, do not show an increased risk for arrhythmias. Late ventricular potentials (LPs), a marker for arrhythmia susceptibility, were rarely found in this FMF cohort.

Area of Science:

  • Cardiology
  • Genetics
  • Rheumatology

Background:

  • Familial Mediterranean fever (FMF) is an autosomal recessive inflammatory disease.
  • FMF can lead to accelerated coronary atherosclerosis and cardiac AA amyloidosis.
  • Late ventricular potentials (LPs) are electrocardiographic markers for ventricular arrhythmia susceptibility.

Purpose of the Study:

  • To evaluate the occurrence of LPs in FMF patients.
  • To compare LP prevalence in FMF patients with and without AA amyloidosis.
  • To assess arrhythmia risk in FMF based on LP presence.

Main Methods:

  • Signal-averaged electrocardiography (SAECG) was performed on 54 colchicine-treated FMF patients.
  • The Frank corrected orthogonal lead system was used for recordings.
  • LPs were identified using established thresholds in averaged electrocardiographic signals.

Main Results:

  • 14 out of 54 FMF patients had biopsy-proven AA amyloidosis.
  • No uncomplicated FMF patients exhibited abnormal or borderline LPs.
  • Only 2 of the 14 FMF patients with amyloidosis had abnormal or borderline LPs.

Conclusions:

  • FMF patients, including those with AA amyloidosis, do not appear to have an increased risk of arrhythmias.
  • LPs were found to be uncommon in this cohort of FMF patients.
  • The study suggests that FMF itself, or its associated amyloidosis, may not significantly elevate arrhythmia risk as indicated by LPs.
Keywords:
AA Amyloidosiscolchicineelectrocardiographyfamilial Mediterranean feverlate ventricular potentialssignal averaged ECG

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