Plasma Leptin and Premenstrual Syndrome: A Review
Zaira Fernanda Martinho Nicolau1, Andréia Gomes Bezerra2, Daniel Ninello Polesel3
1Research Assistant.
Importance:
Premenstrual syndrome (PMS) is characterized by physical and psychological symptoms in the luteal phase. Leptin can influence PMS as it acts on the hypothalamic-pituitary-gonadal axis.
Objective:
The aim of this study was to evaluate data in the literature about the profile of plasma leptin in women with PMS.
Evidence Acquisition:
We performed a search of databases using both descriptors. Three studies were identified. They included 181 participants. Two of these studies found higher leptin levels in women with PMS.
Results:
Conflicting results were found regarding the leptin levels in the luteal phase and the correlation between leptin, estradiol, and progesterone levels.
Conclusions And Relevance:
Leptin could have a role in the pathophysiology of PMS and indicate degree of severity of PMS. Future studies on the role of leptin in PMS are needed.
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