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Two-dimensional echocardiographic findings in systemic sarcoidosis
D J Burstow1, A J Tajik, K R Bailey
1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
The American Journal of Cardiology
|February 15, 1989
Summary
Systemic sarcoidosis can cause cardiac dysfunction, with 14% of patients showing left ventricular systolic dysfunction. Early detection through echocardiography is crucial for managing heart failure and conduction abnormalities in sarcoidosis patients.
Area of Science:
- Cardiology
- Pulmonology
- Rheumatology
Background:
- Systemic sarcoidosis is a multisystem inflammatory disease.
- Cardiac involvement in sarcoidosis can lead to significant morbidity and mortality.
- Echocardiography is a key imaging modality for assessing cardiac function.
Purpose of the Study:
- To define typical echocardiographic abnormalities in patients with systemic sarcoidosis and clinical evidence of cardiac involvement.
- To identify the prevalence of left ventricular systolic dysfunction in these patients.
- To characterize the clinical presentation of cardiac sarcoidosis.
Main Methods:
- Retrospective review of echocardiographic records from 88 patients with systemic sarcoidosis.
- Analysis of echocardiographic findings, including left ventricular systolic function and regional wall motion abnormalities.
- Correlation of echocardiographic findings with clinical data, including heart failure and conduction system disease.
Main Results:
- Twelve patients (14%) exhibited echocardiographic evidence of left ventricular systolic dysfunction attributed to cardiac sarcoidosis.
- Segmental hypokinesis was observed in 8 patients, and global hypokinesis in 4 patients.
- Congestive heart failure (9/12) and conduction system disease (7/12) were common in patients with cardiac dysfunction.
Conclusions:
- Echocardiography can reveal characteristic abnormalities in systemic sarcoidosis patients with cardiac involvement.
- Left ventricular systolic dysfunction is a significant finding in a subset of these patients.
- Cardiac sarcoidosis frequently presents with heart failure and conduction abnormalities, necessitating prompt diagnosis and management.