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Microcystic Calcifying Epithelial Odontogenic Tumor.
Celeste Sánchez-Romero1, Román Carlos2, Oslei Paes de Almeida1
1Oral Pathology, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Head and Neck Pathology
|November 23, 2017
Summary
A rare microcystic variant of calcifying epithelial odontogenic tumor (CEOT) was documented in a Guatemalan female. This case highlights the diagnostic challenges of this unusual CEOT presentation.
Area of Science:
- Oral Pathology
- Oncology
- Odontogenic Tumors
Background:
- Calcifying epithelial odontogenic tumor (CEOT) is a rare odontogenic neoplasm.
- The microcystic variant of CEOT is exceptionally uncommon, presenting diagnostic challenges.
Observation:
- A 42-year-old Guatemalan female presented with an expansile, well-defined lesion in the right posterior mandible.
- Radiographic examination revealed a mixed radiolucent-radiopaque lesion associated with an unerupted third molar.
Findings:
- Histopathology showed nests and cords of pleomorphic epithelial cells with a microcystic pattern.
- Immunohistochemistry confirmed tumor cells positive for AE1/AE3, CK14, CK19, p63, CD138, and beta-catenin.
- Amyloid deposits and calcified material were noted, characteristic of CEOT.
Implications:
- This case underscores the importance of recognizing the microcystic variant of CEOT.
- Awareness of this presentation aids pathologists in differential diagnosis, preventing misdiagnosis.
- Conservative surgical management resulted in no recurrence after one year, suggesting a favorable prognosis for this variant.
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