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Autophagy balances inflammation in innate immunity
Vojo Deretic1,2, Beth Levine3,4,5
1a Autophagy, Inflammation and Metabolism in Disease (AIM) Center of Biomedical Research Excellence , University of New Mexico Health Sciences Center , Albuquerque , NM , USA.
Autophagy
|November 23, 2017
Summary
Autophagy, a key homeostatic process, plays a crucial role in controlling inflammation and shaping both innate and adaptive immunity. This review explores autophagy's links with inflammasomes, interferons, and inflammation during infection.
Area of Science:
- Immunology
- Cell Biology
- Molecular Biology
Background:
- Macroautophagy/autophagy is a fundamental homeostatic mechanism.
- Autophagy significantly impacts immune system regulation.
- Cell-autonomous inflammation control is a key function of autophagy.
Purpose of the Study:
- To review the intricate relationship between autophagy and immune responses.
- To elucidate the role of autophagy in inflammasome activation and interferon signaling.
- To discuss the implications of autophagy in infection-associated inflammation.
Main Methods:
- Literature review focusing on autophagy, immunity, and inflammation.
- Analysis of studies investigating autophagy's role in inflammasome pathways.
- Examination of research on autophagy and interferon responses in infectious diseases.
Main Results:
- Autophagy modulates inflammasome activation, influencing inflammatory signaling.
- Autophagy interacts with interferon pathways, impacting antiviral and antibacterial immunity.
- Dysregulation of autophagy can promote or suppress pathology in various infections.
Conclusions:
- Autophagy is a critical regulator of the immune system, particularly in controlling inflammation.
- Understanding autophagy's interplay with inflammasomes and interferons is vital for managing infectious diseases.
- Targeting autophagy presents potential therapeutic strategies for immune-related pathologies.
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