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Published on: March 29, 2017
Autophagy balances inflammation in innate immunity
Vojo Deretic1,2, Beth Levine3,4,5
1a Autophagy, Inflammation and Metabolism in Disease (AIM) Center of Biomedical Research Excellence , University of New Mexico Health Sciences Center , Albuquerque , NM , USA.
Abstract:
Macroautophagy/autophagy is a homeostatic process with multiple effects on immunity. One of the pivotal contributions of autophagy in immunity is the cell autonomous control of inflammation. This property leads to systemic consequences and thereby influences the development of innate and adaptive immunity, which promotes or suppresses pathology in various disease contexts. In this review we focus on the intersections between autophagy and inflammasome activation, autophagy and interferons, and autophagy and inflammation in association with infection.
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