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Circular RNA profiles in mouse lung tissue induced by radon
Weiwei Pei1,2, Lijing Tao1,2, Leshuai W Zhang3,4
1School of Public Health, Medical College of Soochow University, Suzhou, 215123, China.
Environmental Health and Preventive Medicine
|November 23, 2017
Summary
Radon exposure causes lung injury and inflammation in mice. Differentially expressed circular RNAs (circRNAs) were identified, suggesting their role in radon-induced pulmonary toxicity.
Area of Science:
- Environmental Health
- Molecular Biology
- Toxicology
Background:
- Radon is a known human lung carcinogen with an unclear carcinogenic mechanism.
- Circular RNAs (circRNAs) are non-coding RNAs with diverse biological functions.
- This study investigates circRNA profiles in mouse lung tissue following radon exposure.
Purpose of the Study:
- To analyze circRNA expression changes in mouse lungs exposed to radon.
- To identify potential roles of circRNAs in radon-induced pulmonary toxicity.
Main Methods:
- Mice were exposed to radon (100,000 Bq/m³, 12 h/d) up to 60 WLM.
- Lung tissue damage was assessed via H&E staining and caspase-3 immunohistochemistry.
- circRNA expression profiles were analyzed using microarray, with validation by real-time PCR.
Main Results:
- Radon exposure induced inflammatory reactions and increased caspase-3 expression in mouse lungs.
- Microarray analysis identified 107 upregulated and 83 downregulated circRNAs.
- The expression consistency of the top 5 differentially expressed circRNAs was confirmed.
Conclusions:
- Radon exposure causes significant pulmonary injury in mice.
- Differentially expressed circRNAs are implicated in the pathogenesis of radon-induced lung toxicity.
