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Updated: Feb 18, 2026

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Short two-armed lanthanide-binding tags for paramagnetic NMR spectroscopy based on chiral
Michael D Lee1, Matthew L Dennis, Bim Graham
1Monash Institute of Pharmaceutical Sciences, Monash University, Parkville VIC 3052, Australia. james.swarbrick@monash.edu bim.graham@monash.edu.
Abstract:
A new pair of enantiomeric two-armed lanthanide-binding tags have been developed for paramagnetic NMR studies of proteins. The tags produce large and significantly different paramagnetic effects to one another when bound to the same tagging site. Additionally, they are less sensitive to sample pH than our previous two-armed tag designs.
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