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Related Experiment Videos

Modified bleeding time in the infant.

M Andrew1, V Castle, L Mitchell

  • 1Department of Pediatrics, St. Joseph's Hospital, Hamilton, Ontario, Canada.

American Journal of Hematology
|March 1, 1989
PubMed
Summary
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This study modified the template bleeding time test for newborns. The test effectively identified prolonged bleeding caused by indomethacin and thrombocytopenia in infants.

Area of Science:

  • Neonatal Medicine
  • Hematology
  • Pediatric Surgery

Background:

  • The template bleeding time (BT) is a common diagnostic tool.
  • Assessing BT in newborns presents unique challenges.
  • Standard BT protocols may require modification for neonatal application.

Purpose of the Study:

  • To evaluate a modified template bleeding time (BT) for neonatal use.
  • To determine the sensitivity of the modified BT to specific clinical factors.
  • To assess the impact of indomethacin and thrombocytopenia on neonatal BT.

Main Methods:

  • A modified template bleeding time method was developed for neonates.
  • The study included 242 newborn infants.
  • Sensitivity was tested against antibiotics, indomethacin, illness, and thrombocytopenia.

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Main Results:

  • Both indomethacin and thrombocytopenia significantly prolonged the BT.
  • The BT prolongation due to thrombocytopenia was reversible.
  • Platelet count elevation corrected the bleeding time in affected infants.

Conclusions:

  • The modified template bleeding time is a sensitive indicator in newborns.
  • It can detect bleeding abnormalities related to indomethacin and thrombocytopenia.
  • This modified BT aids in managing neonatal hemostatic disorders.