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The pathogenic detection for 126 children with diarrhea and drug sensitivity tests

X-X Song1, D-H Fang, Y-Q Quan

  • 1Clinical Laboratory, Xuzhou Children's Hospital, Xuzhou, Jiangsu, China. fangdaihua@yeah.net.

European Review for Medical and Pharmacological Sciences
|November 23, 2017
PubMed

Insights

This study identified common causes of infectious diarrhea in children, including bacteria and rotavirus. Antimicrobial drug sensitivity testing is crucial for effective treatment, as overuse of antibiotics can worsen symptoms.

Area of Science:

  • Pediatric Infectious Diseases
  • Microbiology
  • Clinical Pharmacology

Background:

  • Infectious diarrhea is a significant health concern in children.
  • Understanding causative agents and their antimicrobial susceptibility is vital for effective management.
  • Previous studies highlight the need for targeted antimicrobial therapy.

Purpose of the Study:

  • To determine the etiology of infective diarrhea in pediatric patients.
  • To analyze the geographical distribution of infections.
  • To assess the antimicrobial drug sensitivity patterns of common pathogens.

Main Methods:

  • Conducted pathogenic detection and drug sensitivity tests on 126 children with diarrhea.
  • Patients were divided into infant (0-1 year) and child (1-5 years) groups.
  • Microscopic examination of stool samples and antibody detection for rotavirus were performed.

Main Results:

  • Microscopic analysis revealed fat and starch particles in most stool samples.
  • 42 types of pathogenic bacteria were isolated, including 10 Diarrheagenic E. coli strains.
  • 53 samples tested positive for anti-rotavirus antibodies; Staphylococcus aureus, Shigella, Salmonella, and Diarrheagenic E. coli showed high sensitivity to tested antimicrobial agents.

Conclusions:

  • Abuse of antimicrobial agents can lead to intestinal disorders and exacerbate diarrhea.
  • Antimicrobial treatment guided by drug sensitivity testing is fundamental for pediatric diarrhea.
  • This approach ensures targeted therapy and minimizes the risk of antimicrobial resistance.
Abstract

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