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Long-term oral contraceptive use does not affect trabecular bone density.

T Lloyd1, J R Buchanan, G R Ursino

  • 1Department of Obstetrics and Gynecology, College of Medicine, Pennsylvania State University, Hershey 17033.

American Journal of Obstetrics and Gynecology
|February 1, 1989
PubMed
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Long-term oral contraceptive use in premenopausal women does not affect vertebral bone density. This study found similar bone mass in users and non-users, indicating no adverse effects on skeletal health.

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Reproductive Health

Background:

  • Oral contraceptives (OCs) are widely used by premenopausal women.
  • Estrogen in OCs may influence bone density.
  • Long-term effects on trabecular bone mass require investigation.

Purpose of the Study:

  • To assess the impact of long-term exogenous estrogen exposure from oral contraceptives on trabecular bone mass.
  • To compare bone density in premenopausal women with and without a history of oral contraceptive use.

Main Methods:

  • Quantitative single-energy computerized tomography (CT) of L1-3 lumbar vertebral bodies.
  • Study included 25 healthy premenopausal women (11 never-users, 14 long-term users).
  • Oral contraceptive users had taken preparations with ≥50 micrograms mestranol daily for ≥67 months.
Keywords:
BiologyClinical ResearchContraceptionContraceptive AgentsContraceptive Agents, FemaleContraceptive Methods--side effectsDemographic FactorsEndocrine SystemEstrogensFamily PlanningHormonesLongterm EffectsOral Contraceptives--side effectsPhysiologyPopulationPopulation DynamicsReproductive Control AgentsResearch MethodologyTime Factors

Related Experiment Videos

Main Results:

  • Trabecular bone density was comparable between oral contraceptive users (161.2 ± 7.4 mg/ml) and non-users (160.6 ± 6.9 mg/ml).
  • The study had 87% power to detect a 15% difference in bone density.
  • No statistically significant difference in bone density was observed.

Conclusions:

  • Long-term oral contraceptive use in premenopausal women does not negatively impact vertebral trabecular bone density.
  • Exogenous estrogen from oral contraceptives does not appear to alter bone mass in this population.
  • Findings suggest oral contraceptive use is safe concerning vertebral bone density in premenopausal women.