Primary cutaneous follicle center lymphoma

Area of Science:

• Dermatology
• Hematology
• Oncology

Background:

• Cutaneous lymphomas are categorized by cellular origin into T-cell and B-cell types.
• The incidence of cutaneous lymphomas is approximately 0.3 per 100,000 individuals annually.
• Non-Hodgkin lymphomas have demonstrated an increasing incidence over the past decade.

Observation:

• A 56-year-old male patient presented with a two-month history of nodules of varying sizes.
• The nodules were observed on the face, abdomen, and upper limbs, with some exhibiting ulceration.
• The clinical presentation prompted further diagnostic investigation.

Findings:

• Histopathological examination and immunohistochemical studies were performed.
• The diagnostic workup confirmed the presence of primary cutaneous centrofollicular lymphoma.
• This specific subtype represents an uncommon presentation of cutaneous lymphoma.

Implications:

• Primary cutaneous centrofollicular lymphoma is an infrequent condition.
• This case underscores the necessity of including rare cutaneous lymphomas in the differential diagnosis.
• Accurate diagnosis is crucial for appropriate patient management and treatment strategies.