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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Antigen Presenting Cells01:22

Antigen Presenting Cells

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
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Related Experiment Video

Updated: Feb 18, 2026

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs
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Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

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The TCR Takes Some Immune Responsibility.

Ashley A Viehmann Milam1, Paul M Allen1

  • 1Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.

Immunity
|November 23, 2017
PubMed
Summary

The pathogenic response in mice infected with Plasmodium berghei is driven by Vβ8.1 T cells. Mice lacking these T cells do not develop a pathogenic response, indicating the T cell receptor locus acts as an Immune response gene.

Area of Science:

  • Immunology
  • Infectious Disease
  • Genetics

Background:

  • Plasmodium berghei infection in mice can lead to pathogenic responses.
  • The specific immune mechanisms driving this pathogenesis are not fully understood.
  • T cell receptor (TCR) genes play a crucial role in adaptive immunity.

Purpose of the Study:

  • To investigate the role of specific T cell populations in the pathogenesis of Plasmodium berghei infection.
  • To determine if the T cell receptor (TCR) locus can function as an Immune response (Ir) gene in this context.

Main Methods:

  • Utilized a mouse model of Plasmodium berghei infection.
  • Employed genetic analysis to identify key T cell populations involved.
  • Compared disease progression and pathogenic responses in wild-type versus genetically modified mice lacking specific T cell subsets.

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Isolation and Th17 Differentiation of Na&#239;ve CD4 T Lymphocytes
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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

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Related Experiment Videos

Last Updated: Feb 18, 2026

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs
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Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

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Isolation and Th17 Differentiation of Na&#239;ve CD4 T Lymphocytes
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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

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Main Results:

  • The pathogenic response to Plasmodium berghei infection was predominantly mediated by Vβ8.1 T cells.
  • Mice deficient in Vβ8.1 T cells failed to develop a pathogenic response.
  • These findings implicate the TCR locus as an Immune response (Ir) gene.

Conclusions:

  • Vβ8.1 T cells are critical drivers of pathogenesis during Plasmodium berghei infection in mice.
  • The TCR locus can act as an Immune response (Ir) gene, influencing the outcome of parasitic infections.
  • This discovery provides new insights into the genetic control of host-pathogen interactions.