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10:42
Generation and Culturing of Primary Human Keratinocytes from Adult Skin
Published on: December 22, 2017
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Decrease of galectin-3 in keratinocytes: A potential diagnostic marker and a critical contributor to the pathogenesis
Zhen-Rui Shi1, Guo-Zhen Tan1, Cui-Xiang Cao2
1Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Journal of Autoimmunity
|November 24, 2017
Summary
Psoriasis involves decreased epidermal galectin-3 (gal-3) in skin lesions. Restoring gal-3 or blocking neutrophil activity can improve psoriasis symptoms, offering new therapeutic strategies.
Area of Science:
- Dermatology
- Immunology
- Molecular Biology
Background:
- Psoriasis pathogenesis involves dysregulated keratinocyte proteins, but specific targets remain unclear.
- Epidermal galectin-3 (gal-3) expression is significantly reduced in psoriatic skin lesions.
- This downregulation is specific to psoriasis, not other psoriasiform conditions.
Purpose of the Study:
- To investigate the role of epidermal galectin-3 (gal-3) in psoriasis development.
- To identify mechanisms by which gal-3 deficiency promotes psoriatic lesions.
- To explore gal-3-based therapeutic strategies for psoriasis.
Main Methods:
- Analysis of galectin-3 (gal-3) expression in human psoriatic skin and psoriasiform dermatitis.
- Utilizing galectin-3 knockout (gal3-/-) mice and skin grafting models.
- Investigating the role of the JNK pathway and neutrophil accumulation in gal-3 deficient skin.
Main Results:
- Epidermal galectin-3 (gal-3) is significantly downregulated in psoriasis lesions.
- Galectin-3 deficiency exacerbates skin inflammation and promotes psoriatic lesion development in mice.
- Mechanisms include JNK pathway activation and increased neutrophil recruitment via S100A7-9, CXCL-1, and CXCL-8.
- Therapeutic interventions like CXCR2 inhibition and recombinant gal-3 injection improved symptoms in gal-3 deficient mice.
Conclusions:
- Epidermal galectin-3 (gal-3) deficiency is a key factor in psoriasis pathogenesis.
- Galectin-3 plays a protective role against psoriasis development.
- Targeting galectin-3 or neutrophil pathways presents promising diagnostic and therapeutic avenues for psoriasis.
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