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Related Experiment Videos

Association between brain and low back pain.

Shin-Ichi Konno1, Miho Sekiguchi1

  • 1Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Japan.

Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association
|November 24, 2017
PubMed
Summary
This summary is machine-generated.

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Chronic low back pain involves multiple pain types. Brain imaging reveals reduced activation in key pain-regulating areas, suggesting a link between brain function and psychosocial factors in chronic pain.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Orthopedics

Background:

  • Chronic low back pain (CLBP) often involves nociceptive, neuropathic, and nonorganic pain components.
  • Nonorganic pain screening is crucial for comprehensive CLBP assessment.
  • Brain imaging studies implicate the dopamine system in CLBP pathology.

Purpose of the Study:

  • To investigate the role of brain function, particularly the dopamine system, in CLBP.
  • To explore the relationship between psychosocial factors and brain activity in CLBP patients.
  • To assess nonorganic pain using the Brief Scale for Psychiatric Problems in Orthopaedic Patients (BS-POP).

Main Methods:

  • Screening for nonorganic pain using the BS-POP.
  • Utilizing functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) to study brain activity.

Related Experiment Videos

  • Analyzing activation patterns in brain regions associated with pain processing and reward.

    • Main Results:

    • CLBP patients exhibit decreased activation in the anterior cingulate cortex, prefrontal cortex, and nucleus accumbens.
    • These brain regions are involved in the descending inhibitory pain system and dopamine pathways.
    • Reduced activation suggests impaired descending inhibition and potential molecular-level pathology linking psychosocial factors to CLBP.

    Conclusions:

    • Decreased activation in specific brain regions may underlie the pathology of CLBP.
    • A molecular biological basis exists for the connection between psychosocial factors and CLBP.
    • Further investigation into brain function is essential for understanding and treating CLBP.