Related Experiment Video
Updated: Feb 18, 2026
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Ischemic Stroke Profile, Risk Factors, and Outcomes in India: The Indo-US Collaborative Stroke Project
P N Sylaja1, Jeyaraj Durai Pandian2, Subhash Kaul2
1From the Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India (P.N.S., P.K.); Department of Neurology, Christian Medical College and Hospital, Ludhiana, India (J.P., D.A., A.P.); Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India (S.K.); Department of Neurology, All-India Institutes of Medical Sciences, New Delhi (M.V.P.S.); Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India (D.K.); and Department of Neurology, Massachusetts General Hospital, Boston (L.H.S., T.T., A.B.S.). sylajapn@hotmail.com.
Background And Purpose:
The Indo-US Collaborative Stroke Project was designed to characterize ischemic stroke across 5 high-volume academic tertiary hospitals in India.
Methods:
From January 2012 to August 2014, research coordinators and physician coinvestigators prospectively collected data on 2066 patients with ischemic stroke admitted <2 weeks after onset. Investigator training and supervision and data monitoring were conducted by the US site (Massachusetts General Hospital, Boston).
Results:
The mean age was 58.3±14.7 years, 67.2% men. The median admission National Institutes of Health Stroke Scale score was 10 (interquartile range, 5-15) and 24.5% had National Institutes of Health Stroke Scale ≥16. Hypertension (60.8%), diabetes mellitus (35.7%), and tobacco use (32.2%, including bidi/smokeless tobacco) were common risk factors. Only 4% had atrial fibrillation. All patients underwent computed tomography or magnetic resonance imaging; 81% had cerebrovascular imaging. Stroke etiologic subtypes were large artery (29.9%), cardiac (24.9%), small artery (14.2%), other definite (3.4%), and undetermined (27.6%, including 6.7% with incomplete evaluation). Intravenous or intra-arterial thrombolysis was administered in 13%. In-hospital mortality was 7.9%, and 48% achieved modified Rankin Scale score 0 to 2 at 90 days. On multivariate analysis, diabetes mellitus predicted poor 3-month outcome and younger age, lower admission National Institutes of Health Stroke Scale and small-artery etiology predicted excellent 3-month outcome.
Conclusions:
These comprehensive and novel clinical imaging data will prove useful in refining stroke guidelines and advancing stroke care in India.
More Related Videos
Related Concept Videos
01:17Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
01:27Regulation of Stroke Volume
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...