Related Experiment Video
Updated: Feb 18, 2026
Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates
Published on: August 23, 2022
Cholestasis and hypercalcemia secondary to panhypopituitarism in a newborn
Fatma Dursun1, Nelgin Gerenli2, Heves Kırmızıbekmez1
1Departments of Pediatric Endocrinology, Ümraniye Training and Research Hospital, İstanbul, Turkey.
Insights
Congenital hypopituitarism can present with rare symptoms like cholestasis and hypercalcemia in newborns. Early diagnosis is crucial, as these signs may indicate a delayed diagnosis of this endocrine disorder.
Area of Science:
- Pediatric Endocrinology
- Neonatal Medicine
- Hepatology
Background:
- Congenital hypopituitarism is a rare endocrine disorder in newborns.
- Typical symptoms include hypoglycemia, prolonged jaundice, and micropenis.
- Diagnosis is often delayed due to the rarity of presenting symptoms.
Observation:
- A case of congenital hypopituitarism presenting with cholestasis and hypercalcemia is reported.
- Cholestatic hepatitis and hypercalcemia are uncommon manifestations of neonatal hypopituitarism.
- These symptoms can mimic other neonatal conditions, complicating diagnosis.
Findings:
- The study highlights a rare association between congenital hypopituitarism and cholestasis with hypercalcemia.
- This presentation underscores the diagnostic challenges in neonatal endocrine disorders.
- Early recognition of these atypical signs is vital for timely intervention.
Implications:
- Neonatal cholestasis and hypercalcemia warrant consideration of congenital hypopituitarism.
- Prompt endocrinological evaluation is recommended for newborns with these symptoms.
- This case broadens the understanding of hypopituitarism's clinical spectrum in neonates.
Abstract:
Dursun F, Gerenli N, Kırmızıbekmez H. Cholestasis and hypercalcemia secondary to panhypopituitarism in a newborn. Turk J Pediatr 2017; 59: 100-103. Cholestatic hepatitis and hypercalcemia are rare features of hypopituitarism in newborns. So diagnosis of hypopituitarism is frequently delayed. The most frequent symptoms of congenital hypopituitarism are hypoglycemia, prolonged jaundince and micropenis. A patient with congenital hypopituitarism associated with cholestasis and hypercalcemia is reported here. Newborns with hypercalcemia and cholestasis should alert pediatricians to the possibility of congenital hypopituitarism and prompt endocrinological investigation.
Related Concept Videos
01:24Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:30Acute Pancreatitis II: Clinical Manifestations and Management
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
00:59The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
01:17Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
00:51Synthesis and Functions of Calcitonin
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...