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Autonomously Self-Adhesive Hydrogels as Building Blocks for Additive Manufacturing.

Xudong Deng1, Rana Attalla, Lukas P Sadowski

  • 1Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University , Xi'an, 710072, People's Republic of China.

Biomacromolecules
|November 24, 2017
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Summary

Researchers developed rapidly self-adhesive hydrogels for 3D printing functional tissue scaffolds. These dynamic hydrogels quickly regain strength after damage, enabling the creation of robust, cell-supporting structures for tissue engineering applications.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Developing advanced biomaterials is crucial for creating functional tissue scaffolds.
  • Additive manufacturing offers precise control over scaffold architecture.
  • Self-adhesive and rapidly self-healing materials are desirable for complex tissue engineering constructs.

Purpose of the Study:

  • To present a straightforward method for preparing autonomous and rapidly self-adhesive hydrogels.
  • To explore the utility of these hydrogels as building blocks for additive manufacturing of functional tissue scaffolds.
  • To demonstrate the potential of these scaffolds in supporting cell growth for tissue regeneration.

Main Methods:

  • Dynamic cross-linking of hyaluronic acid functionalized with 2-aminophenylboronic acid and poly(vinyl alcohol).
  • Fabrication of interpenetrating networks with calcium-alginate for enhanced mechanical properties.
  • Assessment of hydrogel self-healing capabilities under neutral and acidic pH conditions.
  • Additive manufacturing of hollow perfusion channels using the developed hydrogel system.

Main Results:

  • The synthesized hydrogels exhibited rapid self-adhesion and mechanical integrity recovery within 1 minute after shear or cutting.
  • Incorporation into a calcium-alginate network resulted in an interfacially stiffer, yet still self-adhesive, hydrogel.
  • Hollow perfusion channels were successfully fabricated via additive manufacturing within minutes.
  • These channels demonstrated stability under fluid perfusion and supported endothelial cell proliferation.

Conclusions:

  • A simple and modular method for creating rapidly self-adhesive and self-healing hydrogels was established.
  • These hydrogels serve as effective building blocks for additive manufacturing of functional tissue scaffolds.
  • The developed perfusion channels show promise for applications in vascular tissue engineering and regenerative medicine.