Related Experiment Video

Updated: Feb 18, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

30.9K

Newer direct-acting antivirals for hepatitis C virus infection: Perspectives for India

Varun Gupta1, Ashish Kumar1, Praveen Sharma1

  • 1Institute of Liver, Gastroenterology, & Pancreatico-Biliary Sciences, Sir Ganga Ram Hospital, New Delhi, India.

The Indian Journal of Medical Research
|November 24, 2017
PubMed

Insights

Direct-acting antivirals (DAAs) have revolutionized hepatitis C virus (HCV) treatment, offering high cure rates and better tolerability. Sofosbuvir-based strategies are key for managing HCV genotypes 3 and 1 in India, including cirrhosis.

Area of Science:

  • Hepatology
  • Virology
  • Pharmacology

Background:

  • Chronic hepatitis C virus (HCV) infection affects 170-200 million globally, causing significant mortality and healthcare costs, particularly in India.
  • HCV treatment evolved from interferon (IFN)-based therapies to pegylated-IFN (PEG-IFN) and ribavirin (RBV), with improved tolerability.
  • Direct-acting antivirals (DAAs) represent a revolutionary advancement in HCV treatment, targeting virus-specific proteins.

Purpose of the Study:

  • To review direct-acting antivirals (DAAs) for chronic hepatitis C virus (HCV) infection.
  • To discuss the role of sofosbuvir (SOF) in various HCV genotypes and liver disease stages.
  • To propose SOF-based treatment strategies for prevalent Indian HCV genotypes (3 and 1) and cirrhosis.

Main Methods:

  • Review of existing literature on direct-acting antivirals (DAAs) for hepatitis C virus (HCV).
  • Focus on sofosbuvir (SOF) efficacy, tolerability, and application in different HCV genotypes.
  • Development of treatment strategies incorporating SOF for genotype 3, genotype 1, and cirrhosis.

Main Results:

  • Direct-acting antivirals (DAAs) achieve high HCV cure rates with reduced treatment durations and excellent patient tolerability.
  • Sofosbuvir (SOF) is a highly effective DAA, crucial for HCV management in India due to its availability at a compassionate price.
  • SOF-based regimens are being adopted in India, particularly for prevalent genotypes 3 and 1, and in patients with cirrhosis.

Conclusions:

  • Direct-acting antivirals (DAAs), especially sofosbuvir (SOF), have transformed chronic hepatitis C virus (HCV) treatment globally and in India.
  • SOF-based management strategies offer a highly effective and well-tolerated option for HCV genotypes 3 and 1, including cirrhotic patients.
  • Further development of SOF-based treatment protocols is essential for optimizing HCV care in India.

More Related Videos

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses11:34

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

14.5K
Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

18.5K

Related Concept Videos

Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
49.8K
Subviral Agents01:29

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
621
Retroviruses02:33

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
15.0K
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
1.0K
Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
634