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Updated: Feb 18, 2026
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Use of Synaptic Zinc Histochemistry to Reveal Different Regions and Laminae in the Developing and Adult Brain
Published on: October 29, 2017
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Zinc Signal in Brain Diseases
Stuart D Portbury1, Paul A Adlard2
1The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria 3052, Australia. stuart.portbury@florey.edu.au.
International Journal of Molecular Sciences
|November 24, 2017
Summary
Zinc is essential for brain function, regulating over 300 enzymes and synaptic transmission. Disruptions in zinc homeostasis are linked to neurological disorders like Alzheimer
Area of Science:
- Neuroscience
- Biochemistry
- Cellular Biology
Background:
- Zinc is a vital divalent cation, crucial for over 300 enzymes, intracellular signal transduction, and synaptic transmission in the central nervous system (CNS).
- Cellular zinc distribution and tissue concentrations are tightly regulated by zinc transporters and import proteins.
- Imbalances in brain zinc homeostasis, due to genetic factors or dietary changes, can lead to severe pathological conditions.
Purpose of the Study:
- To review the critical role of zinc signaling within the central nervous system.
- To explore how zinc dysregulation contributes to neurological and psychiatric conditions.
Main Methods:
- Literature review of studies on zinc's role in CNS function and disease.
- Analysis of research linking zinc homeostasis to neurodegenerative and psychiatric disorders.
Main Results:
- Zinc is integral to numerous cellular processes, including enzymatic activity and neurotransmission.
- Dysregulation of zinc transporters and import proteins disrupts brain zinc balance.
- Altered zinc levels are implicated in age-related cognitive decline, depression, Alzheimer's disease, and brain injury outcomes.
Conclusions:
- Zinc signaling plays a significant role in maintaining CNS health.
- Aberrant zinc homeostasis is a potential factor in the pathogenesis of various neurological and psychiatric disorders.
- Further research into zinc's role may reveal novel therapeutic targets for brain conditions.
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