Cyclic di-AMP in host-pathogen interactions
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Updated: Feb 18, 2026

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
Published on: February 22, 2019
Laura Devaux1, Pierre-Alexandre Kaminski2, Patrick Trieu-Cuot2
1Institut Pasteur, Unité Biologie des Bactéries Pathogènes à Gram-positif, CNRS URL3526, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
Abstract:
Cyclic di-AMP (c-di-AMP) is a bacterial signaling nucleotide synthesized by several human pathogens. This widespread and specific bacterial product is recognized by infected host cells to trigger an innate immune response. Detection of c-di-AMP in the host cytosol leads primarily to the induction of type I interferon via the STING-cGAS signaling axis, while being also entangled in the activation of the NF-κB pathway. During their long-standing interaction, host and pathogens have co-evolved to control c-di-AMP activation of innate immunity. On the bacterial side, the quantity of c-di-AMP released inside cells allows to manipulate the host response to exacerbate infection by avoiding immune recognition or, at the opposite, by overloading the STING-cGAS pathway.
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