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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
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Anti-inflammatory agents in peripheral arterial disease
Alexios S Antonopoulos1, Evi Papanikolaou1, Georgia Vogiatzi1
11st Department of Cardiology, Hippokration Hospital, University of Athens, Greece.
Current Opinion in Pharmacology
|November 24, 2017
Summary
Inflammation drives atherosclerotic disease. Anti-inflammatory strategies, including targeted therapies, show promise for treating cardiovascular conditions like peripheral arterial disease.
Area of Science:
- Cardiovascular Medicine
- Immunology
- Pharmacology
Background:
- Inflammation plays a critical role in the development and progression of atherosclerotic diseases, affecting both coronary and peripheral arteries.
- Established evidence from animal models and Mendelian randomization studies links pro-inflammatory cytokines, such as interleukin-6, to increased cardiovascular disease risk.
- Recent clinical trials with interleukin-1β inhibitors have renewed interest in anti-inflammatory treatments for atherosclerosis, including peripheral arterial disease.
Purpose of the Study:
- To review the anti-inflammatory properties of existing cardiovascular drugs.
- To discuss the potential of targeted and non-targeted anti-inflammatory agents in atheroprotection for peripheral arterial disease.
Main Methods:
- Literature review of experimental and clinical studies.
- Analysis of approved cardiovascular drugs for their anti-inflammatory effects.
- Discussion of emerging anti-inflammatory therapies for peripheral arterial disease.
Main Results:
- Approved cardiovascular drugs (e.g., antiplatelets, statins, PCSK9 inhibitors) possess pleiotropic anti-inflammatory effects.
- Targeted anti-inflammatory agents like colchicine, methotrexate, anti-TNF-α agents, and interleukin-targeting monoclonal antibodies are being investigated for peripheral arterial disease.
Conclusions:
- Anti-inflammatory approaches are increasingly recognized as crucial for managing atherosclerotic cardiovascular disease.
- Further research into targeted anti-inflammatory therapies holds significant potential for improving outcomes in peripheral arterial disease.
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